Salinomycin (Procoxacin)，一种钾离子载体抗生素，选择性抑制革兰氏阳性菌的生长(gram-positive bacteria)。Salinomycin 是Wnt/β-catenin 信号传导的有效抑制

2019-05-27

These effects are associated with expressional down-regulation of superoxide dismutase-1 (SOD1) in response to salinomycin treatment. 2019-11-13 · Salinomycin, which has been identified as a selective inhibitor of CSCs in multiple types of cancer, may be an attractive agent against CSCs thereby restrain hepatic metastasis in UM. The objective of the study is to explore the antitumor activity of salinomycin against UM and clarify its underlying mechanism. Se hela listan på drugs.com Salinomycin (Sal), which is a polyether ionophore antibiotic from Streptomyces albus, has been proven to be able to kill different types of human cancer cells, most likely via interfering with ABC drug transporters, the Wnt/β-catenin signaling pathway, or other pathways. Salinomycin produced by Streptomyces albus is a carboxylic polyether ionophore with antibiotic and anti-cancer properties. It induces cell death in some types of cancer cells such as breast, lung, gastric cancer, leukemia and osteosarcoma.

Salinomycin

Salinomycin is used to control coccidia in animals and for growth promotion in ruminants. Salinomycin sodium (SAL‐Na) is active against certain Gram‐positive bacteria, while Gram‐negative species are resistant. SAL‐Na at the proposed concentration is unlikely to increase shedding of Salmonella, Escherichia coli and Campylobacter and or induce resistance and cross‐resistance to antimicrobials important in human and animal Unfortunately Salinomycin sodium salt (Cat. No. 3637) has been withdrawn from sale for commercial reasons.

3637 has been discontinued.

Salinomycin induces massive apoptosis in the multidrug-, radiation- and apoptosis-resistant human cancer cells. Salinomycin-induced apoptosis is independent of tumor suppressor protein p53, caspase activation, the CD95/CD95 ligand system, and the proteasome. Salinomycin fails to induce apoptosis in normal human peripheral CD4+ T lymphocytes.

Millipore Salinomycin S4526-5MG | Sigma-Aldrich. Search term: "Salinomycin S4526-5MG". Compare Products: Select up to 4 products.

Salinomycin reduces the proportion of cancer stem cells(CSC) by >100-fold relative to paclitaxel, a commonly used breast cancer chemotherapeutic drug. Millipore

The monensin caused anorexia within 36 hours and difficulty rising 72 hours after feeding.

Similar Structures. Structure for Salinomycin (DB11544) Salinomycin(Procoxacin) is an antibacterial and coccidiostat ionophore therapeutic drug.; IC50 Value:; Target: Antibacterial; Anticancer; Salinomycin, a polyether ionophore antibiotic isolated from Streptomyces albus, has been shown to kill CSCs in different types of human cancers, The salinomycin come in different sizes, packaging styles, and designs to address the various concerns of individuals and groups. If you are a farmer with many animals, you will find salinomycin in large packages to provide you with optimal transportation convenience. Visit ChemicalBook To find more Salinomycin(53003-10-4) information like chemical properties,Structure,melting point,boiling point,density,molecular formula,molecular weight, physical properties,toxicity information,customs codes. You can also browse global suppliers,vendor,prices,Price,manufacturers of Salinomycin(53003-10-4).
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The substance identifiers displayed in the InfoCard are the best available substance name, EC number, CAS number and/or the molecular and structural formulas. Histopathologically, salinomycin induces severe myocardial and skeletal muscle lesions showing myocardial hyperemia, myocardial fiber degeneration and myocardial mitochondria damage.

Salinomycin is the key compound in the pharmaceutical company Verastem's efforts to produce an anti-cancer-stem-cell drug. Use in agriculture.
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— ≤ 10 g 20- desoxysalinomycin/kg salinomycin sodium. — ≤ 10 g 18,19- dihydrosalinomycin/kg salinomycin sodium. — ≤ 10 g methylated salinomycin/kg salinomycin sodium.

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4 Feb 2020 3.1 Salinomycin but not cisplatin attenuate cancer stem cell properties and promote apoptosis in colon CSCs. Several recent reports suggested

Its extensive adoption is due to its high efficacy, spectral properties and positive effects on drug-resistant pathogens.